Anti-Human IFN-gamma Recombinant Antibody (SAA0266) (HF813013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HF813013

abinScience

种属反应性

Human

ELISA, FCM, Neutralization

IgG1, lambda

SAA0266

Interferon gamma, IFN-gamma, Immune interferon, IFNG, IFN-γ

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P01579

Anti-Human IFNG/IFN-gamma Antibody (SAA0266) (abinScience Cat# HF813013, RRID:AB_3725386)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Interferon gamma (IFNG/IFN-gamma) is a ~19 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.

1. El Bougrini, J. et al. (2006) Cellular and molecular biology (Noisy-le-Grand, France) 52, 9-15. PMID: 16914093

2. Hisamatsu, H. et al. (1996) The Journal of experimental medicine 183, 1807-16. PMID: 8666937

3. Greenlund, AC. et al. (1993) The Journal of biological chemistry 268, 18103-10. PMID: 8349687

4. Akiyama, K. et al. (1994) FEBS letters 343, 85-8. PMID: 8163024

5. Fabunmi, RP. et al. (2001) Journal of cell science 114, 29-36. PMID: 11112687

6. Lah, TT. et al. (1995) FEBS letters 363, 85-9. PMID: 7729559

For research use only.

Isotype Control

Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

SDS-PAGE

SDS-PAGE for Anti-Human IFNG/IFN-gamma Antibody (SAA0266).

产品说明书

Anti-Human IFN-gamma Recombinant Antibody (SAA0266).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IFN-gamma Recombinant Antibody (SAA0266) (HF813013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IFN-gamma Recombinant Antibody (SAA0266) (HF813013)

概述

图片

参考文献

产品说明书

相关产品推荐

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