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InVivoMAb Anti-Mouse TRANCE/TNFSF11/RANK L Antibody (7C6) (MT439010)

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规格：
  • 100ug
  • 1mg
数量：
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概述
货号MT439010
品牌abinScience
描述
InVivoMAb Anti-Mouse CD254/RANKL Antibody (7C6) [7C6] (MT439010) is a mouse monoclonal antibody detecting Tumor necrosis factor ligand superfamily member 11 in ELISA, Neutralization. Suitable for Mouse.
种属反应性Mouse
应用ELISA, Neutralization
同种型VHH-mFc
克隆号7C6
靶标Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, RANKL, TNF-related activation-induced cytokine, TRANCE, CD254, Tumor necrosis factor ligand superfamily member 11, membrane form, Tumor necrosis factor ligand superfamily member 11, soluble form, Tnfsf11, Opgl, Rankl, Trance
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
相关产品 pH 7.4 Dilution Buffer
纯化方式Protein A/G purified from cell culture supernatant.
Accession号O35235
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tumor necrosis factor ligand superfamily member 11 (CD254/RANKL) is a ~35 kDa protein. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. CD254 is the therapeutic target of denosumab (Prolia).

1. Linares, GR. et al. (2012) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27, 1553-65. PMID: 22437732
2. Mahoney, DJ. et al. (2008) The Journal of biological chemistry 283, 25952-62. PMID: 18586671
3. Tiedemann, K. et al. (2013) Journal of cell science 126, 4187-94. PMID: 24039232
4. Omata, Y. et al. (2016) PloS one 11, e0157992. PMID: 27336669
5. Kim, H. et al. (2013) Cell metabolism 17, 249-60. PMID: 23395171
6. Decker, CE. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 15654-9. PMID: 26644563
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlVHH mIgG2a Fc Recombinant Isotype Control Antibody (HyHEL-10) (MP167023)
图片

  • SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Mouse CD254/RANKL Antibody (7C6).

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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InVivoMAb Anti-Mouse TRANCE/TNFSF11/RANK L Antibody (7C6)

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