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Anti-Human BTLA/CD272 Reference Antibody (Tifcemalimab, RUO) (HV375016)

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概述
货号HV375016
品牌abinScience
描述
Tifcemalimab (HV375016) is a research-grade recombinant antibody targeting CD272. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-kappa
表达系统Mammalian cells
靶标B- and T-lymphocyte attenuator, BTLA, CD272, B- and T-lymphocyte-associated protein
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q7Z6A9
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名JS004, Icatolimab, 2236068-83-8
背景

B- and T-lymphocyte attenuator (CD272/BTLA) is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.

1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 12796776
2. Gavrieli, M. et al. (2003) Biochemical and biophysical research communications 312, 1236-43. PMID: 14652006
3. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026
4. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050
5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)
Human IgG4 (S228P & L235E) Recombinant Isotype Control Antibody (HyHEL-10) (HP614107)
Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)
图片

  • Bioactivity

    SEC-HPLC detection for Research Grade Tifcemalimab.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human BTLA/CD272 Reference Antibody (Tifcemalimab, RUO)

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