| 货号 | HV375036 |
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| 品牌 | abinScience |
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| 种属反应性 | Human |
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| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| 同种型 | IgG4-kappa |
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| 克隆号 | ANB032 |
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| 生物活性 | ANB032 reduces dendritic cell maturation in in vitro assays. ANB032 reduces T cell proliferation and secretion of IFN-γ, IL-5, IL-13, and IL-17A, and downregulates BTLA expression during T cell stimulation in PBMCs [1]. ANB032 reduces T cell expansion, plasma inflammatory cytokines, and demonstrates in vivo efficacy in the humanized GvHD mouse model [1]. |
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| 表达系统 | Mammalian cells |
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| 靶标 | B- and T-lymphocyte attenuator, BTLA, CD272, B- and T-lymphocyte-associated protein |
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| 内毒素水平 | < 10 EU/mg |
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| 纯度 | >95% purity as determined by SDS-PAGE. |
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| Accession号 | Q7Z6A9 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
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| 别名 | ANB032 |
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| 背景 | B- and T-lymphocyte attenuator (CD272/BTLA) is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. 1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 127967762. Gavrieli, M. et al. (2003) Biochemical and biophysical research communications 312, 1236-43. PMID: 146520065. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044 |
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| 文献 | 1. Ken Luu, et al. ANB032, a novel BTLA agonist monoclonal antibody, inhibited T cell proliferation, reduced inflammatory cytokines, and down modulated BTLA expression on circulating T and B cells in phase 1, progresses into a phase 2 study in atopic dermatitis. Journal of Investigative Dermatology, 143S106. [HV375036] |
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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| Isotype Control | Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107) |
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