Anti-Human Axl Reference Antibody (Tilvestamab, RUO) (HB709026)

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概述
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参考文献
产品说明书

概述

货号	HB709026
品牌	abinScience
描述	Tilvestamab (HB709026) is a research-grade recombinant antibody targeting UFO. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa
表达系统	Mammalian cells
经测试应用	FCM
靶标	UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P30530
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	Ab-2, BGB-149, 2226775-26-2
背景	Tyrosine-protein kinase receptor UFO (AXL) is a ~98 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

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Bioactivity

SEC-HPLC detection for Research Grade Tilvestamab.
SDS-PAGE

SDS-PAGE for Research Grade Tilvestamab.
Flow CytoMetry

Flow-cytometry using APC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using FITC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

参考文献

产品说明书

Anti-Human Axl Reference Antibody (Tilvestamab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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实验相关试剂

Anti-Human Axl Reference Antibody (Tilvestamab, RUO) (HB709026)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Axl Reference Antibody (Tilvestamab, RUO) (HB709026)

概述

图片

参考文献

产品说明书

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