| 货号 | HB709046 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Humanized |
| 同种型 | IgG1-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P30530 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | BA301, 2460400-28-4 |
| 背景 | Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE (HY-15162) via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011). • Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site., PMID:9178760 • Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias., PMID:9130617 • Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors., PMID:36630517 • The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer., PMID:25568918 • Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia., PMID:39395205 • Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain., PMID:8108112 • Serum AXL is a potential molecular marker for predicting COVID-19 progression., PMID:38799467 • Clinical significance of AXL kinase family in gastric cancer., PMID:12168903 • Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells., PMID:21730355 • The genomic structure of the human UFO receptor., PMID:8381225 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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