| 货号 | HB801016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Chimeric |
| 同种型 | IgG1-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | PRLR, PRL-R, Prolactin receptor |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P16471 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | PR-1594804, h16f, ABBV-176, DC-1630993, h16f, Rolinsatamabtalirine, 2095467-30-2 |
| 背景 | Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C). • Prolactin and autoimmunity., PMID:12848992 • PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance., PMID:36638053 • High plasma prolactin is associated with PRL-R and predicts poor prognosis in Chinese postmenopausal women with breast cancer., PMID:40377604 • Expression of the prolactin receptor (tiPRL-R) gene in tilapia Oreochromis niloticus: tissue distribution and cellular localization in osmoregulatory organs., PMID:10750022 • Biological and clinical aspects of prolactin receptors (PRL-R) in human breast cancer., PMID:2285609 • New insights in prolactin: pathological implications., PMID:25781857 • Detection of prolactin receptor (PRL-R) mRNA in the rat hypothalamus and pituitary gland., PMID:1537321 • Prolactin - a pleiotropic factor in health and disease., PMID:30899100 • Prolactin and its receptor in human endometrium., PMID:10406072 • Increase in prolactin receptor (PRL-R) mRNA level in the mammary gland after hormonal induction of lactation in virgin ewes., PMID:10701763 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Rolinsatamab.
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