Anti-TAG-72 Reference Antibody (HuCC49, RUO) (HP258046)

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概述

货号	HP258046
品牌	abinScience
描述	Anti-TAG-72 Reference Antibody (HuCC49, RUO) (HP258046) is a human monoclonal antibody detecting TAG-72. Expressed in Mammalian cells.
种属反应性	Human
应用	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
宿主	Human
克隆类型	Monoclonal
同种型	IgG1-nd
生物活性	huCC49 potently binds to TAG-72 with a relative affinity constant of 5.65×10 -8 M [1].
表达系统	Mammalian cells
靶标	TAG-72
内毒素水平	< 10 EU/mg as determined by LAL method.
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
状态	Liquid
保存溶液	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	H22, MDX-33, H52, Huh52, HCC49, HuCC49, 823788-82-5
背景	Adenosine 3', 5'-cyclic monophosphate (cAMP) is a key second messenger molecule in intracellular signal transduction. Monitoring cAMP levels is one of the most common ways to screen for agonists and antagonists of G protein–coupled receptors(GPCRs). Bioyeargene cAMP ELISA Kit is based on the competition between HRP-labeled cAMP and free cAMP for fixed amounts of mouse monoclonal anti-cAMP antibody(cAMP MAb) binding sites. Because the concentration of the HRP-labeled cAMP is held constant while the concentration of cAMP varies, the amount of HRP-labeled cAMP that is able to bind to the cAMP MAb will be inversely proportional to the concentration of cAMP in the well. This antigen-antibody complex binds to the goat anti-mouse IgG that has been previously attached to the well. The plate is washed to remove any unbound reagents and then developed. The ELISA typically displays an IC50(50% B/B0) of approximately 12 pmol/mL and a detection limit of approximately 0.15 pmol/mL. • Sphingosine 1-phosphate: Lipid signaling in pathology and therapy., PMID:31624181 • Sphingosine-1-phosphate (S1P) in ovarian physiology and disease., PMID:31455516 • Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases., PMID:32155312 • Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells., PMID:37634735 • Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology., PMID:32278039 • Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration., PMID:31703256 • Sphingosine 1-phosphate (S1P) receptor modulators as an induction and maintenance therapy for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials., PMID:38153524 • S1P (Sphingosine-1-Phosphate)-Induced Vasodilation in Human Resistance Arterioles During Health and Disease., PMID:36070401 • Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair., PMID:28855094 • Sphingosine 1-phosphate signalling., PMID:24346695
文献	1. Kashmiri SV, et al. Development of a minimally immunogenic variant of humanized anti-carcinoma monoclonal antibody CC49. Crit Rev Oncol Hematol. 2001;38(1):3-16. [HP258046]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

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SDS-PAGE

SDS-PAGE for Research Grade HuCC49.

参考文献

产品说明书

Anti-TAG-72 Reference Antibody (HuCC49, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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实验相关试剂

Anti-TAG-72 Reference Antibody (HuCC49, RUO) (HP258046)

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抗体

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实验相关试剂

Anti-TAG-72 Reference Antibody (HuCC49, RUO) (HP258046)

概述

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产品说明书

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