Anti-Human Tau Reference Antibody (DC8E8, RUO) (HY086013)

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100ug
1mg
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概述
图片
参考文献
产品说明书

概述

货号

HY086013

品牌

abinScience

描述

Anti-Human MAPT/Tau/PHF-tau (DC8E8) (HY086013) is a research-grade recombinant antibody targeting MAPTL. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

种属反应性

Human

应用

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

宿主

Human

同种型

IgG4-kappa

克隆号

DC8E8

表达系统

Mammalian cells

克隆类型

Monoclonal

经测试应用

靶标

MAPTL, Paired helical filament-tau, MTBT1, Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, MAPT, PHF-tau

内毒素水平

< 10 EU/mg

纯度

>95% purity as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

P10636

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Microtubule-associated protein tau (MAPT) is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311

2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270

Note

For research use only. Not suitable for clinical or therapeutic use.

图片

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human MAPT/Tau/PHF-tau (DC8E8).
Western blot

Western blot analysis was performed using anti-MAPT/Tau/PHF-tau monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human MAPT/Tau/PHF-tau (Catalog No: HY086012)
Lane 2: negative control
Bioactivity

Detects recombinant human MAPT/Tau/PHF-tau (Catalog No: HY086012) in indirect ELISA

参考文献

产品说明书

Anti-Human Tau Reference Antibody (DC8E8, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Tau Reference Antibody (DC8E8, RUO) (HY086013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Tau Reference Antibody (DC8E8, RUO) (HY086013)

概述

图片

参考文献

产品说明书

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