| 货号 | HY583026 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Humanized |
| 同种型 | IgG1 |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P08887 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | Atlizumab, MRA, R-1569, RHPM-1, RO-4877533, 375823-41-9 |
| 背景 | Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease). • Expression of Interleukin 6 signaling receptors in carotid atherosclerosis., PMID:33350884 • Preclinical development of CD126 CAR-T cells with broad antitumor activity., PMID:33414408 • Physiological effects of modulating the interleukin-6 axis., PMID:29982781 • Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge., PMID:33471392 • IL6 receptor inhibitors: exploring the therapeutic potential across multiple diseases through drug target Mendelian randomization., PMID:39229261 • Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism., PMID:34576053 • Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19., PMID:35634332 • M1-Like Macrophages Modulate Fibrosis and Inflammation of Orbital Fibroblasts in Graves' Orbitopathy: Potential Relevance to Soluble Interleukin-6 Receptor., PMID:36617890 • The IL-6-neutralizing sIL-6R-sgp130 buffer system is disturbed in patients with type 2 diabetes., PMID:31237452 • Soluble interleukin-6 receptor-mediated innate immune response to DNA and RNA viruses., PMID:23946454 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Tocilizumab.
Detects Human CD126/IL6R/IL-6RA in indirect ELISAs.
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