Anti-Human IL-6R alpha/IL6R Reference Antibody (Sarilumab, RUO) (HY583016)

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概述
图片
参考文献
产品说明书

概述

货号

HY583016

品牌

abinScience

描述

Sarilumab (HY583016) is a research-grade recombinant antibody targeting CD126. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

种属反应性

Human

应用

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

同种型

IgG1-kappa

表达系统

Mammalian cells

经测试应用

靶标

sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha

内毒素水平

< 10 EU/mg

纯度

>95% purity as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

P08887

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

REGN88, SAR153191, 1189541-98-7

背景

Interleukin-6 receptor subunit alpha (CD126/IL6R) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.

1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003

2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492

3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509

Note

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

图片

SEC-HPLC

SEC-HPLC detection for Research Grade Sarilumab.
Bioactivity

Detects Human CD126/IL6R/IL-6RA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Anti-Human IL-6R alpha/IL6R Reference Antibody (Sarilumab, RUO)
Western blot

Western blot analysis was performed using anti-CD126/IL6RA monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD126/IL6RA (Catalog No: HY583011)
Lane 2: negative control

参考文献

产品说明书

Anti-Human IL-6R alpha/IL6R Reference Antibody (Sarilumab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IL-6R alpha/IL6R Reference Antibody (Sarilumab, RUO) (HY583016)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IL-6R alpha/IL6R Reference Antibody (Sarilumab, RUO) (HY583016)

概述

图片

参考文献

产品说明书

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