| 货号 | HV263016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG2-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | IL17R, CDw217, IL-17RA, Interleukin-17 receptor A, IL-17 receptor A, IL17RA, CD217 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q96F46 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | AMG827, KHK4827, 1174395-19-7 |
| 背景 | Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis. • From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment., PMID:34201664 • Evaluation of interleukin-17 receptor (IL-17RA) gene expression in PBMCs of patients with premature coronary artery disease., PMID:35913009 • Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling., PMID:38470486 • Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer., PMID:37686343 • Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review)., PMID:39219271 • Loss of Interleukin-17RA Expression is Associated with Tumour Progression in Colorectal Carcinoma., PMID:32462420 • Associations of IL-17 and IL-17 receptor polymorphisms with Behçet's disease in Denizli Province of Turkey., PMID:36701075 • Increased chemokine receptor IL-17RA expression is associated with poor survival in gastric cancer patients., PMID:26261590 • Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop., PMID:32696476 • Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid., PMID:31572359 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Brodalumab.
SDS-PAGE for Research Grade Brodalumab.
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