Anti-Human IL-17RA/IL-17R Reference Antibody (Brodalumab, RUO) (HV263016)

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概述

货号	HV263016
品牌	abinScience
描述	Brodalumab (HV263016) is a research-grade recombinant antibody targeting CD217. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG2-kappa
表达系统	Mammalian cells
经测试应用	FCM
靶标	IL17R, CDw217, IL-17RA, Interleukin-17 receptor A, IL-17 receptor A, IL17RA, CD217
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q96F46
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	AMG827, KHK4827, 1174395-19-7
背景	Interleukin-17 receptor A (CD217/IL17RA) is a ~96 kDa protein. Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A. Receptor for IL17F. Binds to IL17A with higher affinity than to IL17F. Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. 1. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633 2. Yao, Z. et al. (1997) Cytokine 9, 794-800. PMID: 9367539 3. Ely, LK. et al. (2009) Nature immunology 10, 1245-51. PMID: 19838198 4. Toy, D. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 36-9. PMID: 16785495 5. Wright, JF. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 2799-805. PMID: 18684971 6. Puel, A. et al. (2011) Science (New York, N.Y.) 332, 65-8. PMID: 21350122 7. Boisson, B. et al. (2013) Immunity 39, 676-86. PMID: 24120361
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107)

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Bioactivity

SEC-HPLC detection for Research Grade Brodalumab.
SDS-PAGE

SDS-PAGE for Research Grade Brodalumab.
Flow cytometry

Flow-cytometry using anti-human CD217 antibody. THP-1 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD217 monoclonal antibody (Catalog HV263016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.

参考文献

产品说明书

Anti-Human IL-17RA/IL-17R Reference Antibody (Brodalumab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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Anti-Human IL-17RA/IL-17R Reference Antibody (Brodalumab, RUO) (HV263016)

概述

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参考文献

产品说明书

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重组蛋白

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实验相关试剂

Anti-Human IL-17RA/IL-17R Reference Antibody (Brodalumab, RUO) (HV263016)

概述

图片

参考文献

产品说明书

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