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Anti-Human LILRA4/CD85g/ILT7 Reference Antibody (Daxdilimab, RUO) (HX894016)

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概述
货号HX894016
品牌abinScience
描述
Daxdilimab (HX894016) is a research-grade recombinant antibody targeting CD85. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-Lambda
表达系统Mammalian cells
靶标CD85g, ILT7, Immunoglobulin-like transcript 7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, ILT-7, CD85 antigen-like family member G
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P59901
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名MEDI-7734, VIB-7734, 2245966-28-1
背景

Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85g/LILRA4) is a ~55 kDa protein. Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.

1. Cao, W. et al. (2006) The Journal of experimental medicine 203, 1399-405. PMID: 16735691
2. Cao, W. et al. (2009) The Journal of experimental medicine 206, 1603-14. PMID: 19564354
3. Tavano, B. et al. (2014) PloS one 9, e89414. PMID: 24586760
4. Bego, MG. et al. (2015) PLoS pathogens 11, e1005024. PMID: 26172439
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Daxdilimab

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human LILRA4/CD85g/ILT7 Reference Antibody (Daxdilimab, RUO)

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