| 货号 | HW342076 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | ACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P43489 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | KHK4083, KHK-4083, KHK40832431972-52-8 |
| 背景 | Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response • Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077 • OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520 • The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560 • Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970 • An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026 • Entry of betaherpesviruses., PMID:31439151 • OX40 (CD134) and OX40L., PMID:19760068 • Research progress in OX40/OX40L in allergic diseases., PMID:39404736 • The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity., PMID:37932534 • The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Detects CD134/TNFRSF4/OX40 in indirect ELISAs.
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