Anti-Human alpha-Synuclein Reference Antibody (MEDI1341, RUO) (HW755036)

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概述

货号	HW755036
品牌	abinScience
描述	Anti-Human SNCA (MEDI1341) (HW755036) is a research-grade recombinant antibody targeting Alpha-synuclein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG4-kappa
克隆号	MEDI1341
表达系统	Mammalian cells
经测试应用	WB
靶标	Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P37840
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	as1o0452ng1-3, MEDI1341
背景	Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. 1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282 2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590 3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128 4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207) Human IgG4 (S228P & L235E) Recombinant Isotype Control Antibody (HyHEL-10) (HP614107) Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

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SEC-HPLC

SEC-HPLC detection for Research Grade Anti-Human SNCA (MEDI1341).
Bioactivity

Detects SNCA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human SNCA (MEDI1341).
Western blot

Western blot analysis was performed using anti-SNCA monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human SNCA (Catalog No: HW755012), 50ng
Lane 2: recombinant human SNCA (Catalog No: HW755012), 30ng
Lane 3: recombinant human SNCA (Catalog No: HW755012), 20ng
Lane 4: recombinant human SNCA (Catalog No: HW755012), 10ng

参考文献

产品说明书

Anti-Human alpha-Synuclein Reference Antibody (MEDI1341, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

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Anti-Human alpha-Synuclein Reference Antibody (MEDI1341, RUO) (HW755036)

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Anti-Human alpha-Synuclein Reference Antibody (MEDI1341, RUO) (HW755036)

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产品说明书

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