| 货号 | HY525016 |
|---|
| 品牌 | abinScience |
|---|
| 种属反应性 | Human |
|---|
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| 同种型 | IgG1-kappa |
|---|
| 克隆号 | AMG 529 |
|---|
| 生物活性 | AMG-529 induces a dose-dependent increase in alkaline phosphatase (ALP) levels, but no significant effect on blood lipid levels (including non-high-density lipoprotein cholesterol) is observed [1]. |
|---|
| 表达系统 | Mammalian cells |
|---|
| 靶标 | HL-1, ASGP-R 1, Asialoglycoprotein receptor 1, CLEC4H1, ASGR1, C-type lectin domain family 4 member H1, ASGPR 1, Hepatic lectin H1 |
|---|
| 内毒素水平 | < 10 EU/mg |
|---|
| 纯度 | >95% purity as determined by SDS-PAGE. |
|---|
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
|---|
| Accession号 | P07306 |
|---|
| 状态 | Liquid |
|---|
| 保存溶液 |
0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
|---|
| 别名 | AMG-529, AMG529, AMG529 |
|---|
| 背景 | Asialoglycoprotein receptor 1 (ASGR1) is a ~33 kDa protein. Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis. Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway. Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors. 1. Grozovsky, R. et al. (2015) Nature medicine 21, 47-54. PMID: 254859122. Guy, CS. et al. (2011) Hepatology (Baltimore, Md.) 54, 1043-50. PMID: 21656538 |
|---|
| 文献 | 1. Janiszewski M, et al. A randomized, placebo-controlled, double-blind, ascending single-dose, phase 1 study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AMG 529, a novel anti-ASGR1 monoclonal antibody, in healthy subjects. Journal of the American College of Cardiology. 2019 Mar 12;73(9S1):1755-. [HY525016] |
|---|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
|---|
| Isotype Control | Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307) |
|---|
