Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO) (HB103066)

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货号	HB103066
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1
克隆号	SM201
生物活性	SM201 (5 ug/mL) specifically binds to Fc-RIIB on Raji cells and shows no cross-reactivity with Fc-RIIA on K-562 cells [1]. SM201 (0.01-10 ug/mL; 1 h) does not interfere with the binding of IgG to Fc-RIIB on Raji cells [1].
表达系统	Mammalian cells
靶标	IGFR2, FCG2, Fc-gamma RII-b, CDw32, FcRII-b, IgG Fc receptor II-b, CD32, Fc-gamma-RIIb, Low affinity immunoglobulin gamma Fc region receptor II-b, FCGR2B
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P31994
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	SM201
背景	Low affinity immunoglobulin gamma Fc region receptor II-b (CD32b/FCGR2B) is a ~34 kDa protein. Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis.
文献	1. Rieth N, et al. Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells. Immunol Lett. 2014;160(2):145-150. [HB103066]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Bioactivity

Detects CD32b/FCGR2B in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD32b/FCGR2B (SM201).

产品说明书

Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO) (HB103066)

概述

图片

参考文献

产品说明书

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重组蛋白

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实验相关试剂

Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO) (HB103066)

概述

图片

参考文献

产品说明书

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