| 货号 | CB894016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Dog |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Caninized |
| 同种型 | IgG2-kappa-lambda |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | CD52 |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q28896 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | AT-005, AT005, 1608122-71-9 |
| 背景 | Tamtuvetmab (AT-005) is a caninised blontuvetmab against CD52. Tamtuvetmab increases progression-free survival (PFS), exhibits in vivo efficacy in dogs with naïve T-cell lymphoma (LSA). Tamtuvetmab has been approved by veterinary. • CD52 antigen--a review., PMID:11257744 • Anti-CD52 Therapy for Multiple Sclerosis: An Update in the COVID Era., PMID:34268256 • CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma., PMID:37975535 • ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52)., PMID:29447988 • Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors., PMID:38242120 • The immunological function of CD52 and its targeting in organ transplantation., PMID:28283679 • CD52 (CAMPATH1)., PMID:11860230 • Preoperative CD52 Level Predicts Graft Survival following Kidney Transplantation., PMID:39281063 • CD52 and OXPHOS-potential targets in ibrutinib-treated mantle cell lymphoma., PMID:36587029 • CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation., PMID:33731828 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Tamtuvetmab.
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