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Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (Vilamakitug, RUO) (HF802036)

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  • 1mg
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概述
货号HF802036
品牌abinScience
描述
Vilamakitug (HF802036) is a research-grade recombinant antibody targeting IL1F1. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-kappa
表达系统Mammalian cells
靶标IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P01583
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名2458202-06-5
背景

Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.

1. Cohen, I. et al. (2015) Scientific reports 5, 14756. PMID: 26439902
2. Brikos, C. et al. (2007) Molecular & cellular proteomics : MCP 6, 1551-9. PMID: 17507369
3. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091
4. Wu, T. et al. (2004) Cytokine 25, 11-20. PMID: 14687581
5. Spiekstra, SW. et al. (2005) Experimental dermatology 14, 109-16. PMID: 15679580
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Vilamakitug.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (Vilamakitug, RUO)

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