Anti-Clostridioides difficile Toxin A/tcdA Reference Antibody (Actoxumab, RUO) (JN085016)

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概述

货号	JN085016
品牌	abinScience
描述	Actoxumab (JN085016) is a research-grade recombinant antibody targeting Toxin A/tcdA. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Clostridioides difficile
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG1-kappa
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	Toxin A/tcdA
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P16154
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	CDA1, MBL-CDA1, MDX-066, MK-3415A(combinationofactoxumabandbezlotoxumab), 1245634-25-6
背景	Toxin A (tcdA) is a ~308 kDa protein. Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdA and TcdB constitute the main toxins that mediate the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdB, TcdA is less virulent and less important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdA) into the host cytosol. Targets colonic epithelia by binding to some receptor, and enters host cells via clathrin-mediated endocytosis. 1. Kuehne, SA. et al. (2010) Nature 467, 711-3. PMID: 20844489 2. Lyras, D. et al. (2009) Nature 458, 1176-9. PMID: 19252482 3. Greco, A. et al. (2006) Nature structural & molecular biology 13, 460-1. PMID: 16622409 4. Tucker, KD. et al. (1991) Infection and immunity 59, 73-8. PMID: 1670930 5. Tao, L. et al. (2019) Nature microbiology 4, 1760-1769. PMID: 31160825 6. Tao, L. et al. (2016) Nature 538, 350-355. PMID: 27680706 7. Reineke, J. et al. (2007) Nature 446, 415-9. PMID: 17334356 8. Pruitt, RN. et al. (2009) The Journal of biological chemistry 284, 21934-21940. PMID: 19553670
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Actoxumab

参考文献

产品说明书

Anti-Clostridioides difficile Toxin A/tcdA Reference Antibody (Actoxumab, RUO).pdf

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C₁ × V₁ = C₂ × V₂

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母液

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Anti-Clostridioides difficile Toxin A/tcdA Reference Antibody (Actoxumab, RUO) (JN085016)

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Anti-Clostridioides difficile Toxin A/tcdA Reference Antibody (Actoxumab, RUO) (JN085016)

概述

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产品说明书

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