| 货号 | JN085016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Clostridioides difficile |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1-kappa |
| 表达系统 | Mammalian Cells |
| 克隆类型 | Monoclonal |
| 靶标 | Toxin A/tcdA |
| 内毒素水平 | Please contact the lab for this information. |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P16154 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 别名 | CDA1, MBL-CDA1, MDX-066, MK-3415A(combinationofactoxumabandbezlotoxumab), 1245634-25-6 |
| 背景 | Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB. • A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile., PMID:27770789 • Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis., PMID:38922136 • The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins., PMID:26633511 • The enterotoxicity of Clostridium difficile toxins., PMID:22069662 • Comparative biofilm-forming ability between Clostridioides difficile strains isolated in Latin America and the epidemic NAP1/027 strain., PMID:36619751 • The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study., PMID:24708941 • [Effects of Tcd A on Rho GTPases and the Cytoskeleton of Leukemia Cell Line K562]., PMID:30295246 • [Using the real-time PCR assay to establish TaqMan-MGB probe for rapid identification of Clostridium difficile and its toxin]., PMID:25059372 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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