| 货号 | HY515026 |
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| 品牌 | abinScience |
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| 种属反应性 | Human |
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| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| 宿主 | Human |
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| 同种型 | IgG2 |
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| 克隆号 | AMG 820 |
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| 生物活性 | AMG-820 potently inhibits CSF1-driven proliferation of human bone marrow–derived monocytic cells, as well as CSF1- and IL34-driven proliferation of myelomonocytic AML-5 cells [1]. |
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| 表达系统 | Mammalian cells |
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| 克隆类型 | Monoclonal |
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| 靶标 | CD115, CSF-1 receptor, CSF1R, M-CSF-R, CSF-1-R, Proto-oncogene c-Fms, Macrophage colony-stimulating factor 1 receptor, CSF-1R, FMS |
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| 内毒素水平 | < 10 EU/mg |
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| 纯度 | >95% purity as determined by SDS-PAGE. |
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| Accession号 | P07333 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
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| 别名 | AMG-820, AMG820, AMG820 |
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| 背景 | Macrophage colony-stimulating factor 1 receptor (CD115/CSF1R) is a ~107 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. 1. Wei, S. et al. (2010) Journal of leukocyte biology 88, 495-505. PMID: 205049482. Guo, L. et al. (2019) American journal of human genetics 104, 925-935. PMID: 309826093. Oosterhof, N. et al. (2019) American journal of human genetics 104, 936-947. PMID: 30982608 |
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| 文献 | 1. Papadopoulos KP, et al. First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Oct 1;23(19):5703-5710. [HY515026] |
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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