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Anti-Human Serpin E1/PAI-1 Reference Antibody (CT140, RUO) (HY185026)

价格:
规格:
  • 100ug
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
数量:
  • 概述

  • 图片

  • 参考文献

  • 产品说明书

概述
货号HY185026
品牌abinScience
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG4-kappa
克隆号CT140
表达系统Mammalian cells
靶标PLANH1, Endothelial plasminogen activator inhibitor, SERPINE1, Plasminogen activator inhibitor 1, PAI1, PAI, PAI-1, Serpin E1
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P05121
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名CT140
背景

Plasminogen activator inhibitor 1 (SERPINE1/PAI-1) is a ~45 kDa protein. Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading.

1. Szabo, R. et al. (2005) The Biochemical journal 390, 231-42. PMID: 15853774
2. Jankun, J. et al. (2007) International journal of molecular medicine 20, 683-7. PMID: 17912461
3. Lee, MH. et al. (1993) Blood 81, 2357-62. PMID: 8481516
4. Fay, WP. et al. (1997) Blood 90, 204-8. PMID: 9207454
5. Anisuzzaman et al. (2011) Biochemical and biophysical research communications 413, 599-604. PMID: 21925150
6. Planus, E. et al. (1997) Journal of cell science 110 ( Pt 9), 1091-8. PMID: 9175705
7. Degryse, B. et al. (2004) The Journal of biological chemistry 279, 22595-604. PMID: 15001579
8. Kjøller, L. et al. (1997) Experimental cell research 232, 420-9. PMID: 9168821
9. Providence, KM. et al. (2008) Archives of dermatological research 300, 303-10. PMID: 18386027
10. Kortlever, RM. et al. (2006) Nature cell biology 8, 877-84. PMID: 16862142
文献1. Tang Z, et al. Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor. Chem Commun (Camb). 2015 Sep 28;51(75):14263-6. [HY185026]
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)
图片
  • Western blot

    Western blot analysis was performed using anti-human SERPINE1 monoclonal antibody at 1ug/mL on various samples.
    Lane 1: recombinant human SERPINE1 (Catalog No: HY185012)
    Lane 2: negative control

  • Bioactivity

    Detects recombinant human SERPINE1/PAI-1 (Catalog No: HY185012) in indirect ELISA

参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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