| 货号 | HY185016 |
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| 品牌 | abinScience |
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| 种属反应性 | Human |
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| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| 同种型 | IgG1-kappa |
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| 克隆号 | MEDI-579 |
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| 表达系统 | Mammalian cells |
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| 靶标 | PLANH1, Endothelial plasminogen activator inhibitor, SERPINE1, Plasminogen activator inhibitor 1, PAI1, PAI, PAI-1, Serpin E1 |
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| 内毒素水平 | < 10 EU/mg |
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| 纯度 | >95% purity as determined by SDS-PAGE. |
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| Accession号 | P05121 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
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| 别名 | MEDI-579, MEDI579, MEDI579 |
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| 背景 | Plasminogen activator inhibitor 1 (SERPINE1/PAI-1) is a ~45 kDa protein. Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. 1. Szabo, R. et al. (2005) The Biochemical journal 390, 231-42. PMID: 158537742. Jankun, J. et al. (2007) International journal of molecular medicine 20, 683-7. PMID: 179124615. Anisuzzaman et al. (2011) Biochemical and biophysical research communications 413, 599-604. PMID: 219251506. Planus, E. et al. (1997) Journal of cell science 110 ( Pt 9), 1091-8. PMID: 91757057. Degryse, B. et al. (2004) The Journal of biological chemistry 279, 22595-604. PMID: 150015798. Kjøller, L. et al. (1997) Experimental cell research 232, 420-9. PMID: 91688219. Providence, KM. et al. (2008) Archives of dermatological research 300, 303-10. PMID: 1838602710. Kortlever, RM. et al. (2006) Nature cell biology 8, 877-84. PMID: 16862142 |
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| 文献 | 1. Tang Z, et al. Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor. Chem Commun (Camb). 2015 Sep 28;51(75):14263-6. [HY185016] |
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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| Isotype Control | Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307) |
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