Anti-Human CD127/IL-7R alpha Reference Antibody (GSK2618960, RUO) (HB016046)

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货号	HB016046
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa
克隆号	GSK2618960
生物活性	GSK2618960 (10-100 ug/mL; 10 h) potently induces dose-dependent CD4 + T cell proliferation in PBMCs [2]. GSK2618960 binds specifically to monocyte-derived DCs, but not to uncultured primary DCs, NK cells, or B cells from fresh PBMCs [2]. GSK2618960 (50 ug/mL; 7 days) enhances the differentiation of DCs and upregulates their activation marker (CD83, CD86 and CD209) expression in PBMCs [2].
表达系统	Mammalian cells
经测试应用	FCM
靶标	CD127, CDw127, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, IL7R, Interleukin-7 receptor subunit alpha
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P16871
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	GSK2618960
背景	Interleukin-7 receptor subunit alpha (CD127/IL7R) is a ~51 kDa protein. Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
文献	1. Ellis J, et al. Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol. 2019;85(2):304-315. [HB016046] 2. Liao K, et al. Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study. PLoS One. 2021;16(3):e0249049. Published 2021 Mar 23. [HB016046]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) Human IgG1 (E356D/M358L), kappa Recombinant Isotype Control Antibody (HyHEL-10) (HV080013) Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

Bioactivity

Detects Human CD127/IL7R in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD127/IL7R (GSK2618960)
Flow cytometry

Flow-cytometry using APC anti-human CD127 antibody. 293T transfected cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD127 monoclonal antibody (Catalog HB016046, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry using PE anti-human CD127 antibody. 293T transfected cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD127 monoclonal antibody (Catalog HB016046, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human CD127/IL-7R alpha Reference Antibody (GSK2618960, RUO).pdf

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Anti-Human CD127/IL-7R alpha Reference Antibody (GSK2618960, RUO) (HB016046)

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参考文献

产品说明书

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实验相关试剂

Anti-Human CD127/IL-7R alpha Reference Antibody (GSK2618960, RUO) (HB016046)

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图片

参考文献

产品说明书

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