Anti-Human CD266/TNFRSF12A Reference Antibody (BAY-356, RUO) (HV811026)

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货号	HV811026
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	BAY-356
生物活性	BAY-356 induces dose-dependent agonistic effects in TWEAK receptor-positive tumor cells, activating NFκB and STAT1 pathways, increasing TWEAKR expression and IL-8 secretion, activating caspase 3/7, and inhibiting proliferation [1]. BAY-356 (3-10 mg/kg; twice weekly; up to 3 weeks) inhibits tumor growth by 49-71% in TWEAK receptor-positive solid tumor xenograft models [1]. BAY-356 (1-40 mg/kg; i.v.; weekly; 4 weeks) at 10 mg/kg results in well-tolerated exposure in healthy Cynomolgus monkeys, with higher doses (20 and 40 mg/kg) causing slight to moderate organ toxicity [2].
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	FGF-inducible 14, TNFRSF12A, FN14, CD266, TweakR, Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, Tumor necrosis factor receptor superfamily member 12A
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q9NP84
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	BAY-356, BAY356, BAY356
背景	Tumor necrosis factor receptor superfamily member 12A (CD266/TNFRSF12A) is a ~13 kDa protein. Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
文献	1. Berndt S, et al. Abstract 1210: Preclinical pharmacology and repeated dose toxicity of the novel agonistic TWEAK receptor binding antibody BAY-356. Cancer Res. 2016;76(14_Supplement):1210. [HV811026] 2. Viberg A, et al. Abstract 2089: Therapeutic index prediction of the agonistic aglycosylated TWEAK receptor binding antibody BAY-356. Cancer Res. 2016;76(14_Supplement):2089. [HV811026]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CD266/TNFRSF12A (BAY-356)

产品说明书

Anti-Human CD266/TNFRSF12A Reference Antibody (BAY-356, RUO).pdf

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Anti-Human CD266/TNFRSF12A Reference Antibody (BAY-356, RUO) (HV811026)

概述

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参考文献

产品说明书

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重组蛋白

抗体

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实验相关试剂

Anti-Human CD266/TNFRSF12A Reference Antibody (BAY-356, RUO) (HV811026)

概述

图片

参考文献

产品说明书

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