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Research Grade bezeotermin alfa (HB857016)

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  • 1mg
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概述
货号HB857016
品牌abinScience
描述
bezeotermin alfa (HB857016) is a research-grade recombinant antibody targeting bone morphogenetic protein 6/BMP6.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
种属反应性Human
应用ELISA, Functional assay, Research in vivo
宿主Human
种属Human
靶标bone morphogenetic protein 6/BMP6
内毒素水平< 10 EU/mg
纯度>95% as determined by SDS-PAGE.
Accession号P22004
状态Liquid
重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名2935496-94-7
背景

Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target.

1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025
2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087
3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509
4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957
5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108
6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694
NoteFor research use only. Not suitable for clinical or therapeutic use.
图片
参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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