| 货号 | HV974406 |
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| 品牌 | abinScience |
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| 描述 | |
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| 种属反应性 | Human |
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| 应用 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo, WB |
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| 宿主 | Human |
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| 克隆类型 | Monoclonal |
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| 同种型 | IgG4-kappa |
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| 生物活性 | SHR-1701 (10 ug/mL) can inhibit TGF-β signaling pathway, activate PI3K/Akt/Erk signaling pathway, rescue lymphocytes and restore the anti-tumor function of peripheral blood CD8 + T cells in patients with lung cancer [1]. |
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| 经测试应用 | WB |
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| 靶标 | B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1, EC:2.7.11.30, TGF-beta receptor type II, TGF-beta receptor type-2, TGF-beta type II receptor, TGFBR2, TGFR-2, TbetaR-II, Transforming growth factor-beta receptor type II |
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| 内毒素水平 | < 10 EU/mg as determined by LAL method. |
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| 纯度 | >95% as determined by SDS-PAGE. |
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| Accession号 | Q9NZQ7 & P37173 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 产品使用信息 |
| 应用方法 |
稀释比例 |
| WB |
1:500-1:2000 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
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| 别名 | SHR-1701 |
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| 背景 | Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer.
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| 文献 | 1. Bo Cheng, et al. Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer. Cancer Commun (Lond). 2022 Jan;42(1):17-36. [HV974406] |
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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