Anti-Human CX3CR1 Reference Antibody (BI 655089, RUO) (HW331026)
概述
图片
参考文献
产品说明书
概述
货号
HW331026
品牌
abinScience
描述
Anti-Human CX3CR1 Antibody (BI 655089) (HW331026) is a research-grade recombinant antibody targeting CX3CR1. Produced in mammalian cells with native-like glycosylation.
Highlights
●Research Grade — For PK/PD studies, assay development, and ADA research.
Protein A/G purified from cell culture supernatant.
Accession号
P49238
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
BI655089, BI655089, BI-655089
背景
CX3C chemokine receptor 1 (CX3CR1) is a ~40 kDa protein. Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung.
1. Nishimura, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6173-80. PMID: 12055230
2. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415
3. Imai, T. et al. (1997) Cell 91, 521-30. PMID: 9390561
4. Fong, AM. et al. (1998) The Journal of experimental medicine 188, 1413-9. PMID: 9782118
