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Anti-Human Complement Factor B Reference Antibody (Ruxoprubart, RUO) (HF634016)

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概述
货号HF634016
品牌abinScience
描述
Ruxoprubart (HF634016) is a research-grade recombinant antibody targeting Properdin factor B. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-kappa
表达系统Mammalian cells
靶标Properdin factor B, Complement factor B, GBG, Glycine-rich beta glycoprotein, BFD, C3/C5 convertase, CFB, PBF2, BF
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P00751
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名NM-8074, NM8074
背景

Complement factor B (CFB) is a ~85 kDa protein. Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases.

1. Pangburn, MK. et al. (1986) The Biochemical journal 235, 723-30. PMID: 3638964
2. Vogt, W. et al. (1978) Immunology 34, 29-40. PMID: 624565
3. DiScipio, RG. et al. (1983) The Journal of biological chemistry 258, 10629-36. PMID: 6554279
4. Vogel, CW. et al. (1982) The Journal of biological chemistry 257, 8292-9. PMID: 6919543
5. Hourcade, DE. et al. (1998) The Journal of biological chemistry 273, 25996-6000. PMID: 9748277
6. Niemann, MA. et al. (1980) Biochemistry 19, 1576-83. PMID: 6769474
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Ruxoprubart.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human Complement Factor B Reference Antibody (Ruxoprubart, RUO)

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