Anti-Human IL-11 Reference Antibody (BI 765423, RUO) (HB978026)

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货号	HB978026
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG
克隆号	BI 765423
生物活性	In in vitro experiments using human fibroblasts, BI-765423 significantly inhibits fibroblast activation and reduced the progression of inflammation- and senescence-related pathological processes [1] [2]. In in vitro cellular senescence transformation experiments using human cells, BI-765423 effectively counteractes cellular senescence transformation, demonstrating potential anti-aging activity [1]. BI-765423 can extend the healthy lifespan of mammals by inhibiting IL-11 signaling, and also has inhibitory effects on pathological processes associated with idiopathic pulmonary fibrosis (IPF) [1] [2].
表达系统	Mammalian cells
靶标	Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P20809
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	BI-765423, BI765423, BI765423
背景	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
文献	1. Pudewell S, et al. Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies. Front Immunol. 2025 Aug 15;16:1613004. [HB978026] 2. Zhavoronkov A, et al. Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis. Aging (Albany NY). 2025 Aug 16;17(8):1911-1928. [HB978026]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107) Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL11 Antibody (BI 765423)

产品说明书

Anti-Human IL-11 Reference Antibody (BI 765423, RUO).pdf

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Anti-Human IL-11 Reference Antibody (BI 765423, RUO) (HB978026)

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IL-11 Reference Antibody (BI 765423, RUO) (HB978026)

概述

图片

参考文献

产品说明书

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