Research Grade Lutikizumab (HF802026) is a humanized monoclonal antibody detecting IL1F1 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
●Multi-Application — Validated across multiple applications.
种属反应性
Human
应用
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Protein A/G purified from cell culture supernatant.
Accession号
P01583 & P01584
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
Bispecific, ABT-981, 1791411-57-8
背景
Goflikicept (RPH 104) is a fusion protein that selectively binds and inactivates both circulating IL-1β and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI). • Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure., PMID:31836429 • Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis., PMID:33200890 • Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance., PMID:33037057 • The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters., PMID:35139823 • Targeting IL-1β in the Treatment of Atherosclerosis., PMID:33362770 • IL-1 family cytokines in cardiovascular disease., PMID:29198612 • Potential of cannabidiol as acne and acne scar treatment: novel insights into molecular pathways of pathophysiological factors., PMID:38904694 • IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis., PMID:33978542 • Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma., PMID:34159887 • Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies., PMID:32825489
Note
For research use only. Not suitable for clinical or therapeutic use.
Flow-cytometry using APC anti-human IL1A&IL1B antibody. 5637 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an APC anti-human IL1A&IL1B monoclonal antibody (Catalog HF802026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry
Flow-cytometry using anti-human IL1A&IL1B antibody. 5637 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an anti-human IL1A&IL1B monoclonal antibody (Catalog HF802026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
