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Anti-Human IL-13 Reference Antibody (Zumilokibart, RUO) (HW632196)

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规格：
  • 100ug
  • 1mg
  • 5mg
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  • 25mg
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  • 产品说明书

概述
货号HW632196
品牌abinScience
描述
zumilokibart (HW632196) is a research-grade recombinant antibody targeting IL13.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
种属反应性Human
应用ELISA, FACS, Functional assay
宿主Human
同种型IgG1, kappa
靶标IL13
内毒素水平< 10 EU/mg
纯度>95% as determined by SDS-PAGE
Accession号P35225
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名CAS: 3037408-64-0
背景

Interleukin-13 is a ~15 kDa protein. Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells. Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1. Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B.

1. Minty, A. et al. (1993) Nature 362, 248-50. PMID: 8096327
2. McKenzie, AN. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 3735-9. PMID: 8097324
3. Defrance, T. et al. (1994) The Journal of experimental medicine 179, 135-43. PMID: 7903680
4. Luttmann, W. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 157, 1678-83. PMID: 8759755
5. Schnyder, B. et al. (1996) Blood 87, 4286-95. PMID: 8639787
6. Miloux, B. et al. (1997) FEBS letters 401, 163-6. PMID: 9013879
7. Kasaian, MT. et al. (2011) Journal of immunology (Baltimore, Md. : 1950) 187, 561-9. PMID: 21622864
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade zumilokibart

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human IL-13 Reference Antibody (Zumilokibart, RUO)

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