

| 货号 | HB116176 | ||||
|---|---|---|---|---|---|
| 品牌 | abinScience | ||||
| 描述 |
Research Grade rinumafusp alfa (HB116176) is a human monoclonal antibody. Suitable for Human.
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| 种属反应性 | Human | ||||
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 宿主 | Human | ||||
| 同种型 | IgG1, kappa fused with NRG1 | ||||
| 克隆类型 | Monoclonal | ||||
| 内毒素水平 | < 10 EU/mg | ||||
| 纯度 | >95% as determined by SDS-PAGE. | ||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||
| Accession号 | P21860 | ||||
| 状态 | Liquid | ||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Receptor tyrosine-protein kinase erbB-3 (ERBB3/HER3) is a ~148 kDa protein. Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. 1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778 2. Kinugasa, Y. et al. (2004) Biochemical and biophysical research communications 321, 1045-9. PMID: 15358134 3. Braunstein, EM. et al. (2016) Leukemia 30, 2242-2245. PMID: 27416908 | ||||
| Note | For research use only. |

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