Recombinant Human ABCB10 Protein, N-His (PX-P5460)
概述
图片
参考文献
概述
货号
PX-P5460
品牌
ProteoGenix
描述
Recombinant Human ABCB10 Protein, N-His (PX-P5460) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
E. coli Expression — Optimized for functional studies.
表达系统
E. coli
Accession号
Q9NRK6
蛋白长度
Leu492-Ala738
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
29.16 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
ATP-binding cassette sub-family B member 10, mitochondrial (ABCB10) is a ~79 kDa protein. ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria.
1. Tang, L. et al. (2012) British journal of haematology 157, 151-4. PMID: 22085049
2. Yano, M. (2017) Biochemical and biophysical research communications 486, 465-469. PMID: 28315685
3. Seguin, A. et al. (2017) The Journal of biological chemistry 292, 16284-16299. PMID: 28808058
4. Shum, M. et al. (2021) Science translational medicine 13. PMID: 34011630
5. Cao, S. et al. (2023) Nature communications 14, 2030. PMID: 37041204
