Recombinant Human SLC17A5 Protein, N-His (PX-P5925)
概述
图片
参考文献
概述
货号
PX-P5925
品牌
ProteoGenix
描述
Recombinant Human SLC17A5 Protein, N-His (PX-P5925) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
E. coli Expression — Optimized for functional studies.
表达系统
E. coli
Accession号
Q9NRA2
蛋白长度
Thr146-Phe405
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
31.46 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
H(+)/sialic acid cotransporter, H(+)/nitrate cotransporter, Sialin, AST, Vesicular H(+)/Aspartate-glutamate cotransporter, SLC17A5, Membrane glycoprotein HP59, Solute carrier family 17 member 5
背景
Sialin (SLC17A5) is a ~54 kDa protein. Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport. Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system. Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1.
1. Morin, P. et al. (2004) The EMBO journal 23, 4560-70. PMID: 15510212
2. Miyaji, T. et al. (2011) Journal of neurochemistry 119, 1-5. PMID: 21781115
3. Qin, L. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 13434-9. PMID: 22778404
4. Lodder-Gadaczek, J. et al. (2013) The Biochemical journal 454, 31-8. PMID: 23889254
