

| 货号 | PX-P6341 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Recombinant Human FURIN Protein, C-His (PX-P6341) expressed in Mammalian Cells, Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 表达系统 | Mammalian Cells |
| Accession号 | P09958 |
| 蛋白长度 | Met1-Glu715 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 78.90 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | Furin, 3.4.21.75, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, PACE, PCSK3 |
| 背景 | Furin is a ~86 kDa protein. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells. 1. Anderson, ED. et al. (2002) The Journal of biological chemistry 277, 12879-90. PMID: 11799113 2. Leduc, R. et al. (1992) The Journal of biological chemistry 267, 14304-8. PMID: 1629222 3. Barr, PJ. et al. (1991) DNA and cell biology 10, 319-28. PMID: 1713771 4. Wise, RJ. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9378-82. PMID: 2251280 5. Dahms, SO. et al. (2014) ACS chemical biology 9, 1113-8. PMID: 24666235 6. Hardes, K. et al. (2015) ChemMedChem 10, 1218-31. PMID: 25974265 7. Takahashi, S. et al. (1995) The Journal of biological chemistry 270, 26565-9. PMID: 7592877 8. Takahashi, S. et al. (1993) Biochemical and biophysical research communications 195, 1019-26. PMID: 7690548 9. Anderson, ED. et al. (1997) The EMBO journal 16, 1508-18. PMID: 9130696 10. Dubois, CM. et al. (1995) The Journal of biological chemistry 270, 10618-24. PMID: 7737999 |
| Note | For research use only. |

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