Recombinant Human TMPRSS2 Protein, N-His (PX-COV-P044)
概述
图片
参考文献
概述
货号
PX-COV-P044
品牌
ProteoGenix
描述
Recombinant Human TMPRSS2 Protein, N-His (PX-COV-P044) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
E. coli Expression — Optimized for functional studies.
表达系统
E. coli
Accession号
O15393
蛋白长度
Ser284-Gly492
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
25.65 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.
1. Bestle, D. et al. (2020) Life science alliance 3. PMID: 32703818
2. Fraser, BJ. et al. (2022) Nature chemical biology 18, 963-971. PMID: 35676539
3. Wang, H. et al. (2023) Nature communications 14, 7574. PMID: 37990007
4. McCallum, M. et al. (2024) Cell 187, 4231-4245.e13. PMID: 38964328
5. Lucas, JM. et al. (2014) Cancer discovery 4, 1310-25. PMID: 25122198
6. Wilson, S. et al. (2005) The Biochemical journal 388, 967-72. PMID: 15537383
7. Ko, CJ. et al. (2015) Cancer research 75, 2949-60. PMID: 26018085
