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Human KAT2B Recombinant Protein (N-His) (HA390022)

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概述
货号HA390022
品牌abinScience
描述
Recombinant Human KAT2B Protein, N-His (HA390022) expressed in E. coli, spanning Asn651-Lys818. Purity: >90% by SDS-PAGE.
Highlights
  • ●His-Tagged — N-terminal 6×His tag for IMAC purification.
  • ●E. coli Expression — High-yield, cost-effective production.
  • ●High Purity — >90% purity verified by SDS-PAGE.
表达系统E. coli
Accession号Q92831
蛋白长度Asn651-Lys818
应用ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属Homo sapiens (Human)
性质Recombinant
内毒素水平Please contact with the lab for this information.
纯度>90% as determined by SDS-PAGE.
预测分子量22.16 kDa
状态Lyophilized
保存溶液 Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名EC:2.3.1.48, EC:2.3.1.57, Histone acetylase PCAF, Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, KAT2B, Lysine acetyltransferase 2B, P/CAF, P300/CBP-associated factor, PCAF, Spermidine acetyltransferase KAT2B
背景

Histone acetyltransferase KAT2B is a ~93 kDa protein. Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A.

1. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521
2. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905
3. Martínez-Balbás, MA. et al. (2000) The EMBO journal 19, 662-71. PMID: 10675335
4. Xia, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 16564-9. PMID: 23001180
5. Lin, R. et al. (2013) Molecular cell 51, 506-518. PMID: 23932781
6. Chen, S. et al. (2016) Nature communications 7, 10734. PMID: 26867678
7. Fournier, M. et al. (2016) Nature communications 7, 13227. PMID: 27796307
8. Ghosh, TK. et al. (2018) Journal of molecular and cellular cardiology 114, 185-198. PMID: 29174768
9. Zhang, W. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 9855-60. PMID: 9707565
NoteFor research use only
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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