ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
16.19 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
CECR2, Cat eye syndrome critical region protein 2, Chromatin remodeling regulator CECR2, KIAA1740
背景
Chromatin remodeling regulator CECR2 is a ~164 kDa protein. Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex. Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes.
1. Banting, GS. et al. (2005) Human molecular genetics 14, 513-24. PMID: 15640247
2. Filippakopoulos, P. et al. (2012) Cell 149, 214-31. PMID: 22464331
3. Flynn, EM. et al. (2015) Structure (London, England : 1993) 23, 1801-1814. PMID: 26365797
4. Oppikofer, M. et al. (2017) EMBO reports 18, 1697-1706. PMID: 28801535
5. Liu, L. et al. (2002) Genomics 79, 124-36. PMID: 11827465
