Human LILRB2/CD85d/ILT4 Recombinant Protein (C-Fc) (HV255021)
概述
图片
参考文献
产品说明书
概述
货号
HV255021
品牌
abinScience
描述
Recombinant Human CD85d/LILRB2 Protein, C-Fc (HV255021) expressed in Mammalian Cells, spanning Met1-Val461. Purity: >90% by SDS-PAGE.
Highlights
●Fc Fusion — Enhanced stability with Protein A/G purification compatibility.
●Mammalian Expression — Proper folding and native glycosylation.
●High Purity — >90% purity verified by SDS-PAGE.
表达系统
Mammalian cells
Accession号
Q8N423
蛋白长度
Met1-Val461
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
76.39 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
CD85 antigen-like family member D, CD85d, ILT-4, ILT4, Immunoglobulin-like transcript 4, LILRB2, LIR-2, LIR2, Leukocyte immunoglobulin-like receptor 2, Leukocyte immunoglobulin-like receptor subfamily B member 2, MIR-10, MIR10, Monocyte/macrophage immunoglobulin-like receptor 10
背景
Leukocyte immunoglobulin-like receptor subfamily B member 2 is a ~65 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens.
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2. Shiroishi, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8856-61. PMID: 12853576
3. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647
4. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 20448110
5. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042
6. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462
8. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
