Mouse CD365/KIM-1/TIM-1/HAVCR1 Recombinant Protein (C-His) (MV277011)
概述
图片
参考文献
产品说明书
概述
货号
MV277011
品牌
abinScience
描述
Recombinant Mouse CD365/KIM-1/TIM-1/HAVCR1 Protein, C-His (MV277011) expressed in Mammalian Cells, spanning Met1-Gly237. Purity: >90% by SDS-PAGE.
Highlights
●His-Tagged — N-terminal 6×His tag for IMAC purification.
●Mammalian Expression — Proper folding and native glycosylation.
●High Purity — >90% purity verified by SDS-PAGE.
表达系统
Mammalian cells
Accession号
Q5QNS5
蛋白长度
Met1-Gly237
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Mus musculus (Mouse)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
26.81 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
CD365, HAVCR1, HAVcr-1, Hepatitis A virus cellular receptor 1, KIM-1, KIM1, Kidney injury molecule 1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin mucin receptor 1, T-cell membrane protein 1, TIM, TIM-1, TIM1, TIMD-1, TIMD1
背景
Hepatitis A virus cellular receptor 1 homolog is a ~33 kDa protein. Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation.
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3. Xiao, S. et al. (2020) Cell reports 32, 107892. PMID: 32668241
4. Angiari, S. et al. (2014) Immunity 40, 542-53. PMID: 24703780
5. Xiao, S. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1602-8. PMID: 25582854
