

| 货号 | MY573021 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Mouse CD48 Protein, C-Fc (MY573021) expressed in Mammalian Cells, spanning Met1-Arg216. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | Mammalian cells |
| Accession号 | P18181 |
| 蛋白长度 | Met1-Arg216 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Mus musculus (Mouse) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 51.12 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | B-lymphocyte activation marker BLAST-1, BCM1, BCM1 surface antigen, BLAST1, CD48, CD48 antigen, Leukocyte antigen MEM-102, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, TCT.1 |
| 背景 | CD48 antigen is a ~27 kDa protein. Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. 1. Keszei, M. et al. (2011) International immunology 23, 149-58. PMID: 21278219 2. Moran, M. et al. (1998) Immunity 9, 787-96. PMID: 9881969 |
| Note | For research use only |

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