ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
HCRTR2, Hypocretin receptor type 2, ORXR2, OX2R, OXR2, Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R
背景
Orexin receptor type 2 is a ~50 kDa protein. G-protein coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G-proteins thereby initiating distinct downstream signaling cascades. Involved in regulating the sleep-wake cycle. Contributes to central regulation of glucose homeostasis.
1. Yin, J. et al. (2016) Nature structural & molecular biology 23, 293-9. PMID: 26950369
2. Hong, C. et al. (2021) Nature communications 12, 815. PMID: 33547286
3. Yin, J. et al. (2022) Nature communications 13, 2902. PMID: 35614071
4. Sakurai, T. et al. (1998) Cell 92, 573-85. PMID: 9491897
