GMP Grade Human IL-11 (Tag Free) (HB978011)

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100ug
1mg

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概述

货号	HB978011
品牌	abinScience
描述	GMP Grade Human IL-11 (Tag Free) (HB978011) expressed in Mammalian cells. Purity: >95% as determined by SDS-PAGE. by SDS-PAGE. Highlights ●Recombinant — Consistent lot-to-lot performance. ●High Purity — >95% as determined by SDS-PAGE. by SDS-PAGE for demanding downstream applications. ●Bioactive — Verified biological activity.
表达系统	Mammalian cells
Accession号	P20809
蛋白长度	Pro22-Leu199
应用	ELISA, Functional assay
种属	Homo sapiens (Human)
生物活性	Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is <0.5 ng/mL.
性质	Recombinant
内毒素水平	<0.01 EU/ug
纯度	>95% as determined by SDS-PAGE.
预测分子量	19.0 kDa
状态	Lyophilized
保存溶液	Lyophilized from a 0.22 μm-filtered solution containing 20 mM PB, 100 mM Nacl, 5% Mannitol,0.01% Tween 80, pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	AGIF, Adipogenesis inhibitory factor, IL-11, IL11, Interleukin-11, Oprelvekin
背景	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Note	For research use only.

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参考文献

产品说明书

GMP Grade Human IL-11 (Tag Free).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

GMP Grade Human IL-11 (Tag Free) (HB978011)

概述

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重组蛋白

抗体

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GMP Grade Human IL-11 (Tag Free) (HB978011)

概述

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参考文献

产品说明书

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