Angiopoietin-related protein 3 (ANGPTL3) is a ~53 kDa protein. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. 2. Ono, M. et al. (2003) The Journal of biological chemistry 278, 41804-9. PMID: 129096403. Robciuc, MR. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 1706-13. PMID: 236616754. Tikka, A. et al. (2014) Bioscience reports 34, e00160. PMID: 254956455. Shimizugawa, T. et al. (2002) The Journal of biological chemistry 277, 33742-8. PMID: 120973246. Lee, EC. et al. (2009) The Journal of biological chemistry 284, 13735-13745. PMID: 193183557. Liu, J. et al. (2010) The Journal of biological chemistry 285, 27561-70. PMID: 205813958. Shimamura, M. et al. (2007) Arteriosclerosis, thrombosis, and vascular biology 27, 366-72. PMID: 171106029. Shan, L. et al. (2009) The Journal of biological chemistry 284, 1419-24. PMID: 1902867610. Shimamura, M. et al. (2003) Biochemical and biophysical research communications 301, 604-9. PMID: 12565906 | 
