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InVivoMAb Anti-Human alpha-Synuclein Antibody (9E4#) (HW755050)

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规格：
  • 100ug
  • 1mg
数量：
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概述
货号HW755050
品牌abinScience
描述
InVivoMAb Anti-Human SNCA Antibody (9E4#) [9E4#] (HW755050) is a human monoclonal antibody detecting SNCA in ELISA, Neutralization. Suitable for Human.
种属反应性Human
应用ELISA, Neutralization
同种型IgG1, kappa
克隆号9E4#
靶标SNCA
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
相关产品 pH 7.4 Dilution Buffer
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P37840
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging.

1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282
2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590
3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128
4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407)
Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)
图片

  • SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Human SNCA Antibody (9E4#).

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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