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InVivoMAb Anti-Mouse CCR8 Antibody (Iv0255) (MW444010)

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规格：
  • 100ug
  • 1mg
数量：
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概述
货号MW444010
品牌abinScience
描述
InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0255) [Iv0255] (MW444010) is a mouse monoclonal antibody detecting C-C chemokine receptor type 8 in ELISA, Neutralization. Suitable for Mouse.
种属反应性Mouse
应用ELISA, Neutralization
同种型IgG2a, kappa
克隆号Iv0255
靶标C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
相关产品 pH 7.4 Dilution Buffer
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P56484
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production.

1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461
2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588
3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlMouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)
图片

  • SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0255)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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