InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (14F12) (HW601020)

价格:

规格：

100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HW601020

品牌

abinScience

描述

InVivoMAb Anti-Human CD110/TPOR Antibody (14F12) [14F12] (HW601020) is a human monoclonal antibody detecting TPO-R in Agonist, ELISA. Suitable for Human.

种属反应性

Human

应用

Agonist, ELISA

宿主

Human

同种型

IgG1

克隆号

14F12

克隆类型

Monoclonal

靶标

TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110

内毒素水平

Please contact with the lab for this information.

纯度

>95% as determined by SDS-PAGE.

相关产品

pH 7.4 Dilution Buffer

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

P40238

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

重悬

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Interleukin-17A (CD110/TPOR) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites.

1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225

2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317

3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948

4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068

5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633

6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703

Note

For research use only. Not suitable for clinical or therapeutic use.

图片

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human CD110/TPOR Antibody (14F12)

参考文献

产品说明书

InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (14F12).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (14F12) (HW601020)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (14F12) (HW601020)

概述

图片

参考文献

产品说明书

相关产品推荐

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