Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760) (HP790013)

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50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HP790013

品牌

abinScience

描述

Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760) (HP790013) is a human monoclonal antibody detecting TRPM4/LTRPC4 in ELISA, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, WB

宿主

Human

克隆类型

Monoclonal

同种型

VHH-hFc

克隆号

SAA0760

经测试应用

靶标

LTRPC4, Transient receptor potential cation channel subfamily M member 4, TRPM4, Melastatin-4, LTrpC-4, hTRPM4, Calcium-activated non-selective cation channel 1, LTrpC4, Long transient receptor potential channel 4

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

Q8TD43

RRID

Anti-Human TRPM4/LTRPC4 Antibody (SAA0760) (abinScience Cat# HP790013, RRID:AB_3726306)
_x005F_x000D_

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

背景

Transient receptor potential cation channel subfamily M member 4 (TRPM4/LTRPC4) is a ~134 kDa protein. Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production.

1. Launay, P. et al. (2002) Cell 109, 397-407. PMID: 12015988

2. Hofmann, T. et al. (2003) Current biology : CB 13, 1153-8. PMID: 12842017

3. Winkler, PA. et al. (2017) Nature 552, 200-204. PMID: 29211723

4. Wang, H. et al. (2019) The Journal of investigative dermatology 139, 1089-1097. PMID: 30528822

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-TRPM4 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Jurkat cell lysate
Lane 2: PC12 cell lysate
Lane 3: Rat brain lysate
Western blot

Western blot analysis was performed using anti-TRPM4 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Jurkat cell lysate
Lane 2: PC12 cell lysate
Lane 3: 23T cell lysate

参考文献

产品说明书

Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760) (HP790013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760) (HP790013)

概述

图片

参考文献

产品说明书

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