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Anti-Human beta-2 Adrenergic R/ADRB2 Recombinant Nanobody (SAA1156) (HY357033)

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  • 50ug
  • 100ug
  • 1mg
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概述
货号HY357033
品牌abinScience
描述
Anti-Human ADRB2 Nanobody (SAA1156) [SAA1156] (HY357033) is a alpaca monoclonal antibody detecting ADRB2 in FCM. Suitable for Human.
Highlights
  • ●Flow Cytometry — Validated for flow cytometry applications.
种属反应性Human
应用FCM
宿主Alpaca
克隆类型Monoclonal
同种型VHH-8His-Cys-tag
克隆号SAA1156
靶标Beta-2 adrenergic receptor, ADRB2R, Beta-2 adrenoreceptor, ADRB2, B2AR, Beta-2 adrenoceptor
内毒素水平< 10 EU/mg as determined by LAL method.
纯度>95% as determined by SDS-PAGE.
纯化方式Purified by Nickel column.
Accession号P07550
状态Liquid
保存溶液 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Beta-2 adrenergic receptor is a ~46 kDa protein. G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways. ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively. Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate. Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway.

1. Zhu, WZ. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 1607-12. PMID: 11171998
2. Wang, Y. et al. (2008) The Journal of biological chemistry 283, 1799-807. PMID: 18056263
3. Allen, JM. et al. (1988) The EMBO journal 7, 133-8. PMID: 2834198
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human ADRB2 Nanobody (SAA1156)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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